Microbubbles coupled to methotrexate-loaded liposomes for ultrasound-mediated delivery of methotrexate across the blood–brain barrier

Methotrexate (MTX) is the single most effective agent for the treatment of primary central nervous system lymphoma. Currently, the delivery of MTX to the brain is achieved by high systemic doses, which cause severe long-term neurotoxicity, or intrathecal administration, which is highly invasive and...

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Detalhes bibliográficos
Main Authors: Wang, Xiang, Liu, Ping, Yang, Weixiao, Li, Lu, Li, Peijing, Liu, Zheng, Zhuo, Zhongxiong, Gao, Yunhua
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211917/
https://ncbi.nlm.nih.gov/pubmed/25364248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S69845
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