Src Mutation Induces Acquired Lapatinib Resistance in ERBB2-Amplified Human Gastroesophageal Adenocarcinoma Models

ERBB2-directed therapy is now a routine component of therapy for ERBB2-amplified metastatic gastroesophageal adenocarcinomas. However, there is little knowledge of the mechanisms by which these tumors develop acquired resistance to ERBB2 inhibition. To investigate this question we sought to characte...

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Detalhes bibliográficos
Main Authors: Hong, Yong Sang, Kim, Jihun, Pectasides, Eirini, Fox, Cameron, Hong, Seung-Woo, Ma, Qiuping, Wong, Gabrielle S., Peng, Shouyong, Stachler, Matthew D., Thorner, Aaron R., Van Hummelen, Paul, Bass, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211679/
https://ncbi.nlm.nih.gov/pubmed/25350844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109440
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