A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains

Herpes Simplex Virus type-1 (HSV-1) and type-2 (HSV-2) establish life-long infections and cause significant orofacial and genital infections in humans. HSV-1 is the leading cause of infectious blindness in the western world. Currently, there are no available vaccines to protect against herpes simple...

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Main Authors: Stanfield, Brent A., Stahl, Jacque, Chouljenko, Vladimir N., Subramanian, Ramesh, Charles, Anu-Susan, Saied, Ahmad A., Walker, Jason D., Kousoulas, Konstantin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211657/
https://ncbi.nlm.nih.gov/pubmed/25350288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109890
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