Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses

BACKGROUND: Herpes simplex virus type-1(HSV-1) and HSV-2 are important human pathogens that cause significant ocular and urogenital complications, respectively. We have previously shown that HSV-1 virions lacking glycoprotein K (gK) are unable to enter into neurons via synaptic axonal membranes and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Iyer, Arun V, Pahar, Bapi, Chouljenko, Vladimir N, Walker, Jason D, Stanfield, Brent, Kousoulas, Konstantin G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826548/
https://ncbi.nlm.nih.gov/pubmed/24165088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-317
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados