Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis

Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the effi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Naidu, Shan K., Nabi, Rafiq, Cheemarla, Nagarjuna R., Stanfield, Brent A., Rider, Paul J., Jambunathan, Nithya, Chouljenko, Vladimir N., Carter, Renee, Del Piero, Fabio, Langohr, Ingeborg, Kousoulas, Konstantin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004361/
https://ncbi.nlm.nih.gov/pubmed/32027675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228252
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