Covalent Small Molecule Inhibitors of Ca(2+)-Bound S100B

[Image: see text] Elevated levels of the tumor marker S100B are observed in malignant melanoma, and this EF-hand-containing protein was shown to directly bind wild-type (wt) p53 in a Ca(2+)-dependent manner, dissociate the p53 tetramer, and inhibit its tumor suppression functions. Likewise, inhibiti...

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Bibliografiske detaljer
Main Authors: Cavalier, Michael C., Pierce, Adam D., Wilder, Paul T., Alasady, Milad J., Hartman, Kira G., Neau, David B., Foley, Timothy L., Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Toth, Eric A., Weber, David J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211652/
https://ncbi.nlm.nih.gov/pubmed/25268459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5005552
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