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Novel protein–inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography
Structure-based drug discovery is under way to identify and develop small-molecule S100B inhibitors (SBiXs). Such inhibitors have therapeutic potential for treating malignant melanoma, since high levels of S100B downregulate wild-type p53 tumor suppressor function in this cancer. Computational and X...
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| 出版年: | Acta Crystallogr D Struct Biol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
International Union of Crystallography
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4908867/ https://ncbi.nlm.nih.gov/pubmed/27303795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798316005532 |
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