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Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress
Premature senescence induced by oncogenic stimuli or tumor suppressor activation plays opposing roles in tumorigenesis. Here, we propose that galectin-3, a β-galactoside-binding lectin, regulates premature senescence without oncogenic stress. We detected premature senescence, decreased Skp2, and inc...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4211374/ https://ncbi.nlm.nih.gov/pubmed/24971481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.88 |
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