Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress

Premature senescence induced by oncogenic stimuli or tumor suppressor activation plays opposing roles in tumorigenesis. Here, we propose that galectin-3, a β-galactoside-binding lectin, regulates premature senescence without oncogenic stress. We detected premature senescence, decreased Skp2, and inc...

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Detalhes bibliográficos
Main Authors: Kim, S-J, Lee, H-W, Gu Kang, H, La, S-H, Choi, Il Ju, Ro, J Y, Bresalier, R S, Song, J, Chun, K-H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211374/
https://ncbi.nlm.nih.gov/pubmed/24971481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.88
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