Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism

The human Telomerase Reverse Transcriptase (hTERT) gene encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity. Suppression of hTERT expression could induce cellular senescence and is considered a potent approach for gastric cancer therapy. However, control of hTERT...

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Bibliographic Details
Published in:Oncotarget
Main Authors: La, Sun-Hyuk, Kim, Seok-Jun, Kang, Hyeok-Gu, Lee, Han-Woong, Chun, Kyung-Hee
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302977/
https://ncbi.nlm.nih.gov/pubmed/27494887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10986
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