Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress

Premature senescence induced by oncogenic stimuli or tumor suppressor activation plays opposing roles in tumorigenesis. Here, we propose that galectin-3, a β-galactoside-binding lectin, regulates premature senescence without oncogenic stress. We detected premature senescence, decreased Skp2, and inc...

Full description

Saved in:
Bibliographic Details
Main Authors: Kim, S-J, Lee, H-W, Gu Kang, H, La, S-H, Choi, Il Ju, Ro, J Y, Bresalier, R S, Song, J, Chun, K-H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
Subjects:
Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211374/
https://ncbi.nlm.nih.gov/pubmed/24971481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.88
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items