The prion protein protease sensitivity, stability and seeding activity in variably protease sensitive prionopathy brain tissue suggests molecular overlaps with sporadic Creutzfeldt-Jakob disease

INTRODUCTION: Variably protease sensitive prionopathy (VPSPr) is a recently described, sporadic human prion disease that is pathologically and biochemically distinct from the currently recognised sporadic Creutzfeldt-Jakob disease (sCJD) subtypes. The defining biochemical features of the abnormal fo...

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Main Authors: Peden, Alexander H, Sarode, Deep P, Mulholland, Carl R, Barria, Marcelo A, Ritchie, Diane L, Ironside, James W, Head, Mark W
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210614/
https://ncbi.nlm.nih.gov/pubmed/25331173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0152-4
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