Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

BACKGROUND: Mounting evidence suggests that soluble oligomers of amyloid-β (oAβ) represent the pertinent synaptotoxic form of Aβ in sporadic Alzheimer’s disease (AD); however, the mechanistic links between oAβ and synaptic degeneration remain elusive. Most in vivo experiments to date have been limit...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Price, Katherine A, Varghese, Merina, Sowa, Allison, Yuk, Frank, Brautigam, Hannah, Ehrlich, Michelle E, Dickstein, Dara L
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210526/
https://ncbi.nlm.nih.gov/pubmed/25312309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-41
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