Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell proliferation....

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Bibliografiska uppgifter
Huvudupphovsmän: Drosten, Matthias, Sum, Eleanor Y. M., Lechuga, Carmen G., Simón-Carrasco, Lucía, Jacob, Harrys K. C., García-Medina, Raquel, Huang, Sidong, Beijersbergen, Roderick L., Bernards, Rene, Barbacid, Mariano
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210339/
https://ncbi.nlm.nih.gov/pubmed/25288756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417549111
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