Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell proliferation....

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Dettagli Bibliografici
Autori principali: Drosten, Matthias, Sum, Eleanor Y. M., Lechuga, Carmen G., Simón-Carrasco, Lucía, Jacob, Harrys K. C., García-Medina, Raquel, Huang, Sidong, Beijersbergen, Roderick L., Bernards, Rene, Barbacid, Mariano
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210339/
https://ncbi.nlm.nih.gov/pubmed/25288756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417549111
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