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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway
The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell proliferation....
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210339/ https://ncbi.nlm.nih.gov/pubmed/25288756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417549111 |
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