Human TLR10 is an anti-inflammatory pattern-recognition receptor

Toll-like receptor (TLR)10 is the only pattern-recognition receptor without known ligand specificity and biological function. We demonstrate that TLR10 is a modulatory receptor with mainly inhibitory effects. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, inc...

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Bibliografiske detaljer
Main Authors: Oosting, Marije, Cheng, Shih-Chin, Bolscher, Judith M., Vestering-Stenger, Rachel, Plantinga, Theo S., Verschueren, Ineke C., Arts, Peer, Garritsen, Anja, van Eenennaam, Hans, Sturm, Patrick, Kullberg, Bart-Jan, Hoischen, Alexander, Adema, Gosse J., van der Meer, Jos W. M., Netea, Mihai G., Joosten, Leo A. B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210319/
https://ncbi.nlm.nih.gov/pubmed/25288745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410293111
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