Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

IL-1 family member IL-37 limits innate inflammation in models of colitis and LPS-induced shock, but a role in adaptive immunity remains unknown. Here, we studied mice expressing human IL-37b isoform (IL-37tg) subjected to skin contact hypersensitivity (CHS) to dinitrofluorobenzene. CHS challenge to...

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Detalhes bibliográficos
Main Authors: Luo, Yuchun, Cai, Xiangna, Liu, Sucai, Wang, Sen, Nold-Petry, Claudia A., Nold, Marcel F., Bufler, Philip, Norris, David, Dinarello, Charles A., Fujita, Mayumi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210310/
https://ncbi.nlm.nih.gov/pubmed/25294929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416714111
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