Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

IL-37 is a fundamental inhibitor of innate immunity. Human IL-37 has a caspase-1 cleavage site and translocates to the nucleus upon LPS stimulation. Here, we investigated whether caspase-1 processing affects IL-37–mediated suppression of LPS-induced cytokines and the release from cells by analyzing...

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Detalhes bibliográficos
Main Authors: Bulau, Ana-Maria, Nold, Marcel F., Li, Suzhao, Nold-Petry, Claudia A., Fink, Michaela, Mansell, Ashley, Schwerd, Tobias, Hong, Jaewoo, Rubartelli, Anna, Dinarello, Charles A., Bufler, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932872/
https://ncbi.nlm.nih.gov/pubmed/24481253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324140111
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