Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific acce...

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Main Authors: Kreher, Stephan, Bouhlel, M. Amine, Cauchy, Pierre, Lamprecht, Björn, Li, Shuang, Grau, Michael, Hummel, Franziska, Köchert, Karl, Anagnostopoulos, Ioannis, Jöhrens, Korinna, Hummel, Michael, Hiscott, John, Wenzel, Sören-Sebastian, Lenz, Peter, Schneider, Markus, Küppers, Ralf, Scheidereit, Claus, Giefing, Maciej, Siebert, Reiner, Rajewsky, Klaus, Lenz, Georg, Cockerill, Peter N., Janz, Martin, Dörken, Bernd, Bonifer, Constanze, Mathas, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210307/
https://ncbi.nlm.nih.gov/pubmed/25288773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406985111
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