ASP4058, a Novel Agonist for Sphingosine 1-Phosphate Receptors 1 and 5, Ameliorates Rodent Experimental Autoimmune Encephalomyelitis with a Favorable Safety Profile

Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that acts through the members of a family of five G protein-coupled receptors (S1P(1)–S1P(5)). S1P(1) is a major regulator of lymphocyte trafficking, and fingolimod, whose active metabolite fingolimod phosphate acts as a nonselectiv...

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Bibliographic Details
Main Authors: Yamamoto, Rie, Okada, Youhei, Hirose, Jun, Koshika, Tadatsura, Kawato, Yuka, Maeda, Masashi, Saito, Rika, Hattori, Kazuyuki, Harada, Hironori, Nagasaka, Yasuhisa, Morokata, Tatsuaki
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210206/
https://ncbi.nlm.nih.gov/pubmed/25347187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110819
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