A sphingosine‐1‐phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration

BACKGROUND AND PURPOSE: Intracranial aneurysm (IA), common in the general public, causes lethal subarachnoid haemorrhage on rupture. It is, therefore, of utmost importance to prevent the IA from rupturing. However, there is currently no medical treatment. Recent studies suggest that IA is the result...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Yamamoto, Rie, Aoki, Tomohiro, Koseki, Hirokazu, Fukuda, Miyuki, Hirose, Jun, Tsuji, Keiichi, Takizawa, Katsumi, Nakamura, Shinichiro, Miyata, Haruka, Hamakawa, Nozomu, Kasuya, Hidetoshi, Nozaki, Kazuhiko, Hirayama, Yoshitaka, Aramori, Ichiro, Narumiya, Shuh
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466536/
https://ncbi.nlm.nih.gov/pubmed/28409823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13820
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