Down Regulation of Wnt Signaling Mitigates Hypoxia-Induced Chemoresistance in Human Osteosarcoma Cells

Osteosarcoma (OS) is the most common type of solid bone cancer and remains the second leading cause of cancer-related death for children and young adults. Hypoxia is an element intrinsic to most solid-tumor microenvironments, including that of OS, and is associated with resistance to therapy, poor s...

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Bibliographic Details
Main Authors: Scholten, Donald J., Timmer, Christine M., Peacock, Jacqueline D., Pelle, Dominic W., Williams, Bart O., Steensma, Matthew R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210185/
https://ncbi.nlm.nih.gov/pubmed/25347326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111431
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