Aerosol Azacytidine Inhibits Orthotopic Lung Cancers in Mice through Its DNA Demethylation and Gene Reactivation Effects

We devised an aerosol based demethylation therapy to achieve therapeutic efficacy in premalignant or in situ lesions of lung cancer, without systemic toxicity. Optimum regimens of aerosolized azacytidine (Aza) were designed and used in orthotopic human non-small cell lung cancer xenograft models. Th...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Qiu, Xuan, Liang, Yuanxin, Sellers, Rani S., Perez-Soler, Roman, Zou, Yiyu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210052/
https://ncbi.nlm.nih.gov/pubmed/25347303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109874
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