Immunoglobulin Free Light Chains and GAGs Mediate Multiple Myeloma Extracellular Vesicles Uptake and Secondary NfκB Nuclear Translocation

Multiple myeloma (MM) is a hematological malignancy caused by a microenviromentally aided persistence of plasma cells in the bone marrow. Monoclonal plasma cells often secrete high amounts of immunoglobulin free light chains (FLCs) that could induce tissue damage. Recently, we showed that FLCs are i...

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Bibliografische gegevens
Hoofdauteurs: Di Noto, Giuseppe, Chiarini, Marco, Paolini, Lucia, Mazzoldi, Elena Laura, Giustini, Viviana, Radeghieri, Annalisa, Caimi, Luigi, Ricotta, Doris
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2014
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209816/
https://ncbi.nlm.nih.gov/pubmed/25386176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00517
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