Immunoglobulin Free Light Chains and GAGs Mediate Multiple Myeloma Extracellular Vesicles Uptake and Secondary NfκB Nuclear Translocation

Multiple myeloma (MM) is a hematological malignancy caused by a microenviromentally aided persistence of plasma cells in the bone marrow. Monoclonal plasma cells often secrete high amounts of immunoglobulin free light chains (FLCs) that could induce tissue damage. Recently, we showed that FLCs are i...

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Bibliografski detalji
Glavni autori: Di Noto, Giuseppe, Chiarini, Marco, Paolini, Lucia, Mazzoldi, Elena Laura, Giustini, Viviana, Radeghieri, Annalisa, Caimi, Luigi, Ricotta, Doris
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2014
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209816/
https://ncbi.nlm.nih.gov/pubmed/25386176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00517
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