A new tumour suppression mechanism by p27(Kip1): EGFR down-regulation mediated by JNK/c-Jun pathway inhibition

p27(Kip1) is a potent inhibitor of cyclin-dependent kinases that drive G(1)-to-S cell-cycle transition. Reduced p27(Kip1) expression is prevalent in a wide range of human tumours; however, the exact mechanism(s) of p27(Kip1)-mediated tumour suppression remains obscure. In the present study, we ident...

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Main Authors: Fang, Yong, Wang, Yihong, Wang, Yulei, Meng, Yan, Zhu, Junlan, Jin, Honglei, Li, Jingxia, Zhang, Dongyun, Yu, Yonghui, Wu, Xue-Ru, Huang, Chuanshu
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209780/
https://ncbi.nlm.nih.gov/pubmed/25121353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140103
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