FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4(+) T regulatory cells

INTRODUCTION: Multiple myeloma (MM) development involves a series of genetic abnormalities and changes in the bone marrow (BM) microenvironment, favoring the growth of the tumor and failure of local immune control. T regulatory (Treg) cells play an important role in dampening anti-tumor immune respo...

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Hauptverfasser: Braga, Walter Moises Tobias, da Silva, Bruna Raphaeli, de Carvalho, Ana Carolina, Maekawa, Yumi H., Bortoluzzo, Adriana Bruscato, Rizzatti, Edgar Gil, Atanackovic, Djordje, Colleoni, Gisele Wally Braga
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209089/
https://ncbi.nlm.nih.gov/pubmed/25099367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-014-1589-9
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