Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway

Combination therapy, which can optimize killing activity to cancers and minimize drug resistance, is a mainstream therapy against hormone-refractory prostate cancers (HRPCs). Rottlerin, a natural polyphenolic component, synergistically increased PC-3 (a HRPC cell line) apoptosis induced by camptothe...

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Detalhes bibliográficos
Main Authors: Hsu, Jui-Ling, Ho, Yunn-Fang, Li, Tsai-Kun, Chen, Ching-Shih, Hsu, Lih-Ching, Guh, Jih-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208915/
https://ncbi.nlm.nih.gov/pubmed/22490701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.023
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