Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin‐treated, apolipoprotein E‐deficient mice

The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2. To determine the contribution of these dicarbonyls to t...

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Main Authors: Geoffrion, Michèle, Du, Xueliang, Irshad, Zehra, Vanderhyden, Barbara C., Courville, Kerri, Sui, Guangzhi, D'Agati, Vivette D., Ott‐Braschi, Sylvie, Rabbani, Naila, Thornalley, Paul J., Brownlee, Michael, Milne, Ross W.
Format: Artigo
Jezik:Inglês
Izdano: Wiley Periodicals, Inc. 2014
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208644/
https://ncbi.nlm.nih.gov/pubmed/24920125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12043
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