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Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice

Differences in susceptibility to diabetic nephropathy (DN) between mouse strains with identical levels of hyperglycemia correlate with renal levels of oxidative stress, shown previously to play a central role in the pathogenesis of DN. Susceptibility to DN appears to be genetically determined, but t...

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Detalhes bibliográficos
Main Authors: Giacco, Ferdinando, Du, Xueliang, D’Agati, Vivette D., Milne, Ross, Sui, Guangzhi, Geoffrion, Michele, Brownlee, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868051/
https://ncbi.nlm.nih.gov/pubmed/24062246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0316
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