Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1

The mechanisms controlling the development of dendritic cells (DCs) remain incompletely understood. Using an Mysm1 knockout (Mysm1(−/−)) mouse model, we identified the histone H2A deubiquitinase Mysm1, as a critical regulator in DC differentiation. Mysm1(−/−) mice showed a global reduction of DCs in...

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Bibliographic Details
Main Authors: Won, Haejung, Nandakumar, Vijayalakshmi, Yates, Peter, Sanchez, Suzi, Jones, Lindsey, Huang, Xue F., Chen, Si-Yi
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208280/
https://ncbi.nlm.nih.gov/pubmed/25217698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-534313
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