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The LIMP-2/SCARB2 Binding Motif on Acid β-Glucosidase: BASIC AND APPLIED IMPLICATIONS FOR GAUCHER DISEASE AND ASSOCIATED NEURODEGENERATIVE DISEASES

The acid β-glucosidase (glucocerbrosidase (GCase)) binding sequence to LIMP-2 (lysosomal integral membrane protein 2), the receptor for intracellular GCase trafficking to the lysosome, has been identified. Heterologous expression of deletion constructs, the available GCase crystal structures, and bi...

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Autori principali: Liou, Benjamin, Haffey, Wendy D., Greis, Kenneth D., Grabowski, Gregory A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208013/
https://ncbi.nlm.nih.gov/pubmed/25202012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593616
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