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Participation of Asparagine 370 and Glutamine 235 in the Catalysis by Acid β-Glucosidase: The Enzyme deficient in Gaucher disease
The hydrolysis of glucosylceramide by acid β-glucosidase proceeds via a two-step, double displacement mechanism that includes cleavage of the O-β-glucosidic bond, enzyme-glucosylation and, then, enzyme-deglucosylation. Two residues that may impact this cycle are N370 and E235. The N370S mutant enzym...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699545/ https://ncbi.nlm.nih.gov/pubmed/19217815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2009.01.006 |
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