PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade

Mechanistic target of rapamycin (mTOR) integrates multiple extracellular and intracellular signals to regulate cell growth and survival. Hyperactivation of mTOR has been observed in various cancers. Regulation of mTOR activity is thus of importance in physiological processes and tumor development. H...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Zhibo, Chen, Xinxin, Wang, Ying, Peng, Haiyong, Wang, Yanan, Jing, Yanling, Zhang, Hongbing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207987/
https://ncbi.nlm.nih.gov/pubmed/25164809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584821
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