Targeting of Splice Variants of Human Cytochrome P450 2C8 (CYP2C8) to Mitochondria and Their Role in Arachidonic Acid Metabolism and Respiratory Dysfunction

In this study, we found that the full-length CYP2C8 (WT CYP2C8) and N-terminal truncated splice variant 3 (∼44-kDa mass) are localized in mitochondria in addition to the endoplasmic reticulum. Analysis of human livers showed that the mitochondrial levels of these two forms varied markedly. Molecular...

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Detalhes bibliográficos
Main Authors: Bajpai, Prachi, Srinivasan, Satish, Ghosh, Jyotirmoy, Nagy, Leslie D., Wei, Shouzou, Guengerich, F. Peter, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207977/
https://ncbi.nlm.nih.gov/pubmed/25160618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.583062
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