Nilotinib Is More Potent than Imatinib for Treating Plexiform Neurofibroma In Vitro and In Vivo

Plexiform neurofibromas (PNFs) are benign nerve sheath tumors mostly associated with neurofibromatosis type 1. They often extend through multiple layers of tissue and therefore cannot be treated satisfactorily by surgery. Nilotinib is a tyrosine kinase inhibitor used to treat leukemia, with advantag...

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Bibliografiske detaljer
Main Authors: Wei, Jiang, Freytag, Marcus, Schober, Yvonne, Nockher, Wolfgang A., Mautner, Victor F., Friedrich, Reinhard E., Manley, Paul W., Kluwe, Lan, Kurtz, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207688/
https://ncbi.nlm.nih.gov/pubmed/25340526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107760
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