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Modeling Dynamics of Cell-to-Cell Variability in TRAIL-Induced Apoptosis Explains Fractional Killing and Predicts Reversible Resistance

Isogenic cells sensing identical external signals can take markedly different decisions. Such decisions often correlate with pre-existing cell-to-cell differences in protein levels. When not neglected in signal transduction models, these differences are accounted for in a static manner, by assuming...

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Detalhes bibliográficos
Main Authors: Bertaux, François, Stoma, Szymon, Drasdo, Dirk, Batt, Gregory
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207462/
https://ncbi.nlm.nih.gov/pubmed/25340343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003893
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