Myeloma cells inhibit osteogenic differentiation of mesenchymal stem cells and kill osteoblasts via TRAIL-induced apoptosis

INTRODUCTION: Myeloma bone disease (MBD) is the result of the increased activity of osteoclasts (OCs), which is not accompanied by a comparable increase of osteoblast (OB) function, thus leading to enhanced bone resorption. Osteoblasts can also regulate osteoclast activity through expression of cyto...

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Bibliografiske detaljer
Main Authors:	Fu, Jinxiang, Wang, Panjun, Zhang, Xiaohui, Ju, Suguang, Li, Jie, Li, Binzhou, Yu, Sun, Zhang, Jianhua, Zhang, Xueguang
Format:	Artigo
Sprog:	Inglês
Udgivet:	Termedia Publishing House 2010
Fag:	Basic Research
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3284062/ https://ncbi.nlm.nih.gov/pubmed/22371791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/aoms.2010.14459
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Myeloma cells inhibit osteogenic differentiation of mesenchymal stem cells and kill osteoblasts via TRAIL-induced apoptosis

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