In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

Dysfunctional endothelium contributes to more disease than any other tissue in the body. Small interfering RNAs (siRNAs) have the potential to help study and treat endothelial cells in vivo by durably silencing multiple genes simultaneously, but efficient siRNA delivery has so far remained challengi...

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Detalhes bibliográficos
Main Authors: Dahlman, James E., Barnes, Carmen, Khan, Omar, Thiriot, Aude, Jhunjunwala, Siddharth, Shaw, Taylor E., Xing, Yiping, Sager, Hendrik B., Sahay, Gaurav, Speciner, Lauren, Bader, Andrew, Bogorad, Roman L., Yin, Hao, Racie, Tim, Dong, Yizhou, Jiang, Shan, Seedorf, Danielle, Dave, Apeksha, Sandu, Kamaljeet S., Webber, Matthew J., Novobrantseva, Tatiana, Ruda, Vera M., Lytton-Jean, Abigail K.R., Levins, Christopher G., Kalish, Brian, Mudge, Dayna K., Perez, Mario, Abezgauz, Ludmila, Dutta, Partha, Smith, Lynelle, Charisse, Klaus, Kieran, Mark W., Fitzgerald, Kevin, Nahrendorf, Matthias, Danino, Dganit, Tuder, Rubin M., von Andrian, Ulrich H., Akinc, Akin, Schroeder, Avi, Panigrahy, Dipak, Kotelianski, Victor, Langer, Robert, Anderson, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207430/
https://ncbi.nlm.nih.gov/pubmed/24813696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nnano.2014.84
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