The Roles of Individual Mammalian Argonautes in RNA Interference In Vivo

Argonaute 2 (Ago2) is the only mammalian Ago protein capable of mRNA cleavage. It has been reported that the activity of the short interfering RNA targeting coding sequence (CDS), but not 3′ untranslated region (3′UTR) of an mRNA, is solely dependent on Ago2 in vitro. These studies utilized extremel...

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Bibliographic Details
Main Authors: Ruda, Vera M., Chandwani, Rohit, Sehgal, Alfica, Bogorad, Roman L., Akinc, Akin, Charisse, Klaus, Tarakhovsky, Alexander, Novobrantseva, Tatiana I., Koteliansky, Victor
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081796/
https://ncbi.nlm.nih.gov/pubmed/24992693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101749
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