Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition

The nucleus accumbens (NAc) has a central role in the mechanism of action of drugs of abuse. The major neuronal type within the NAc is the GABAergic medium spiny neuron (MSN), with two major subpopulations defined—termed D1-type and D2-type MSNs—based on the predominant dopamine receptor expressed....

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Bibliographische Detailangaben
Hauptverfasser: Koo, Ja Wook, Lobo, Mary Kay, Chaudhury, Dipesh, Labonté, Benoit, Friedman, Allyson, Heller, Elizabeth, Peña, Catherine Jensen, Han, Ming-Hu, Nestler, Eric J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207344/
https://ncbi.nlm.nih.gov/pubmed/24853771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.118
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