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Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1

A hallmark of protein conformational disease, exemplified by neurodegenerative disorders, is the expression of misfolded and aggregated proteins. The relationship between protein aggregation and cellular toxicity is complex, and various models of experimental pathophysiology have often yielded confl...

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Bibliografiske detaljer
Main Authors: Kitamura, Akira, Inada, Noriko, Kubota, Hiroshi, Matsumoto, Gen, Kinjo, Masataka, Morimoto, Richard I., Nagata, Kazuhiro
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207061/
https://ncbi.nlm.nih.gov/pubmed/24450587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gtc.12125
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