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Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1
A hallmark of protein conformational disease, exemplified by neurodegenerative disorders, is the expression of misfolded and aggregated proteins. The relationship between protein aggregation and cellular toxicity is complex, and various models of experimental pathophysiology have often yielded confl...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207061/ https://ncbi.nlm.nih.gov/pubmed/24450587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gtc.12125 |
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