Uncovering divergent evolution of α/β-hydrolases: a surprising residue substitution needed to convert Hevea brasiliensis hydroxynitrile lyase into an esterase

Lignende værker

• Increasing the reaction rate of hydroxynitrile lyase from Hevea brasiliensis towards mandelonitrile by copying active site residues from an esterase that accepts aromatic esters
  af: von Langermann, Jan, et al.
  Udgivet: (2014)
• Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis.
  af: Zuegg, J., et al.
  Udgivet: (1999)
• Catalytic promiscuity of ancestral esterases and hydroxynitrile lyases
  af: Devamani, Titu, et al.
  Udgivet: (2016)
• Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity
  af: Jones, Bryan J., et al.
  Udgivet: (2020)
• The cyanogenic syndrome in rubber tree Hevea brasiliensis: tissue-damage-dependent activation of linamarase and hydroxynitrile lyase accelerates hydrogen cyanide release
  af: Kadow, Daniel, et al.
  Udgivet: (2012)