CXCR4 Expression, CXCR4 Activation, and Wild Type NPM1 Are Independently Associated with Unfavorable Prognosis in Patients with Acute Myeloid Leukemia

BACKGROUND: CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation and is essential for migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts unfavorable prognosis in patients with acute myeloid leukemia (AML). Nucleophosmin (NPM1) mutation is the most frequen...

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Hauptverfasser: Konoplev, Sergej, Lin, Pei, Yin, C. Cameron, Lin, E., González, Graciela M. Nogueras, Kantarjian, Hagop M., Andreeff, Michael, Medeiros, L. Jeffrey, Konopleva, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206258/
https://ncbi.nlm.nih.gov/pubmed/24035716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clml.2013.05.013
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