Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. The molecular chaperones act in pre...

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Библиографические подробности
Главные авторы: Kung, Pin-Jui, Tao, Yu-Chen, Hsu, Ho-Chiang, Chen, Wan-Ling, Lin, Te-Hsien, Janreddy, Donala, Yao, Ching-Fa, Chang, Kuo-Hsuan, Lin, Jung-Yaw, Su, Ming-Tsan, Wu, Chung-Hsin, Lee-Chen, Guey-Jen, Hsieh-Li, Hsiu-Mei
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2014
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206201/
https://ncbi.nlm.nih.gov/pubmed/25342886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S67376
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