Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults.

Analysis of the reactivity of IgM with self-antigens in tissues by a quantitative immunoblotting technique showed striking invariance among newborns in the human and in the mouse. The self-reactive repertoire of IgM of adults was also markedly conserved; it comprised most anti-self reactivities that...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Mouthon, L, Nobrega, A, Nicolas, N, Kaveri, S V, Barreau, C, Coutinho, A, Kazatchkine, M D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731992/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3839
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