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Delayed Ras/PKA signaling augments the unfolded protein response
During environmental, developmental, or genetic stress, the cell’s folding capacity can become overwhelmed, and misfolded proteins can accumulate in all cell compartments. Eukaryotes evolved the unfolded protein response (UPR) to counteract proteotoxic stress in the endoplasmic reticulum (ER). Altho...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4205644/ https://ncbi.nlm.nih.gov/pubmed/25275008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409588111 |
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