Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity

V domain-containing Ig suppressor of T-cell activation (VISTA) is a negative checkpoint regulator that suppresses T cell-mediated immune responses. Previous studies using a VISTA-neutralizing monoclonal antibody show that VISTA blockade enhances T-cell activation. The current study describes a compr...

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Bibliographic Details
Main Authors: Wang, Li, Le Mercier, Isabelle, Putra, Juan, Chen, Wenna, Liu, Jun, Schenk, Austin D., Nowak, Elizabeth C., Suriawinata, Arief A., Li, Jiannan, Noelle, Randolph J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205642/
https://ncbi.nlm.nih.gov/pubmed/25267631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407447111
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