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A Signaling Network Induced by β(2) Integrin Controls the Polarization of Lytic Granulesin Cytotoxic Cells
Cytotoxic lymphocyte skill target cells by polarized release of the content of perforin-containing granules. In natural killer cells, the binding of β(2) integrin to its ligand ICAM-1 is sufficient to promote not only adhesion but also lytic granule polarization. This provided a unique opportunity t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4205566/ https://ncbi.nlm.nih.gov/pubmed/25292215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005629 |
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